Effectiveness of tranexamic acid for reducing intraoperative bleeding in palatoplasties: A randomized clinical trial.

BACKGROUND: Few data are available regarding blood loss during cleft palate surgery. This study assessed the effect of using tranexamic acid in the reduction of intraoperative bleeding. METHODS: A double-blind, randomized clinical trial compared intraoperative bleeding and the incidence of oronasal fistulas after palatoplasties in a control group that was given placebo and an intervention group that was given 10 mg/kg tranexamic acid followed by a continuous infusion of 1 mg/kg/h of the same until the end of surgery. Patients who underwent primary palatoplasty with no known or suspected coagulation disorders at our institution during the study period were included in the study. RESULTS: 70 patients were allocated, 66 received the intervention. Blood loss was reduced by 11.9%, without statistical significance. The incidence of fistulas in the intervention and control groups was 12.9% and 18.75%, respectively. The reduction of 5.8% (CI 95%: 12%-23.8%) was not significant. CONCLUSIONS: The reduction of intraoperative blood loss was lower than expected and not statistically significant; a larger sample is needed to confirm the observed reduction. The drug did not seem to have negative effects on flap viability.

Cirurgia plástica pós-gastroplastia: perfil das deficiências nutricionais com implicações na cicatrização / Plastic surgery after gastroplasty: nutritional deficiency profile with wound-healing implications

INTRODUÇÃO: Os cirurgiões plásticos têm recebido em seus consultórios e ambulatórios um número cada vez maior de pacientes com queixa de deformidade do contorno corporal após maciças perdas ponderais secundárias a cirurgias bariátricas. Todavia, em função das restrições alimentares e disabsorções cirúrgicas, são frequentes complicações metabólicas e distúrbios nutricionais no pós-operatório tardio das gastroplastias. O objetivo deste estudo é detectar a prevalência dos principais distúrbios nutricionais relacionados à cicatrização em pacientes de ambulatório especializado em cirurgia plástica do paciente pós-gastroplastia. MÉTODO: é um estudo observacional, transversal e descritivo, em que os pacientes foram avaliados clinicamente e através de protocolo laboratorial. RESULTADOS: foram avaliados 32 pacientes com gastroplastia há pelo menos dois anos e estabilidade ponderal há no mínimo seis meses. Os principais distúrbios detectados foram: anemia (56% dos pacientes), com carências na bioquímica do ferro (31,2%) e da vitamina B12 (25%), bem como deficiências dos íons zinco (18,7%) e cobre (3,1%). Houve carências discretas no perfil proteico e ausência de déficits na bioquímica básica e lipidograma. CONCLUSÃO: é dever do cirurgião plástico conhecer a fundo a prevalência dos principais distúrbios nutricionais relacionados à cicatrização na população de pacientes pós-gastroplastia no sentido de corrigir eventuais carências e prevenir complicações. Sabe-se, contudo, que ainda são necessários mais estudos para correlacionar qualquer deficiência alimentar às intercorrências observadas no pós-operatório deste grupo de pacientes.

INTRODUCTION: Plastic surgeons have received in their outpatient clinics an increasing number of patients complaining of body contour defects due to the massive weight loss after a bariatric surgery. However, owing to dietary restrictions and surgical desorption, metabolic complications and nutritional disorders are commonly observed in the late postoperative period after gastroplasty. The aim of this study was to determine the prevalence of major nutritional disorders related to healing in patients at a specialized outpatient plastic surgery clinic who underwent gastroplasty. METHOD: This is an observational, transversal, and descriptive study, in which a laboratory protocol was used to clinically evaluate and assess the patients. RESULTS: Thirty-two patients who underwent gastroplasty at least 2 years previously with weight stability for at least 6 months were evaluated. The major disorders identified included anemia (56% of patients) and deficiency in iron (31.2%), vitamin B12 (25%), zinc ions (18.7%), and copper (3.1%). Mild deficiencies in the protein profile were also observed; however, no deficiencies in basic and lipid biochemistry were noted. CONCLUSION: The plastic surgeon should have an in-depth knowledge about the prevalence of the major nutritional disorders related to healing in postbariatric patients, to allow correction of possible deficiencies and prevention of complications. However, more studies would be required to correlate any dietary deficiency to the complications observed in the postoperative period in this group of patients.